We examined the ability of short-wave infrared (IR) light in the λ1.5-3.0 μm region of the infrared emission spectrum to accomplish C-Cπ bond construction reaction between π-excessive azaheteroaromatic and different carbonyl substrates supported on a bentonitic clay catalyst in solventless condition via a three-component condensation reaction. Preliminary studies show that the implementation of a domestic Flavor-Wave® oven fitted with a halogen heater lamp as a chemical reactor was as effective as the use of near IR light (λ1.1 μm) in fostering batch-wise organic reactions. Overall, this approach reveals its potential exploitation as an energy-efficient source to assemble biologically engaging (hetero)arenebisindolylmethanes framework, in the same way, that assure its sustainable development as for efficient generation of small libraries of molecules comparable to high-tech instrumentations performances.

Cell growth and division are highly regulated processes, although a notable exception is provided by the cancer cell, which arises as a variant that has lost the usual proliferation control pathways. Consequently, there is growing interest in the search for antitu-moral substances with high efficacy, low toxicity, and minimum side effects. In this sense, we synthesize eight diindolylmethane derivatives and the in vitro antitumor activity against murine L5178Y lymphoma cells was assessed. The preliminary results showed that the substituent and its position on the phenyl group were important for its potency against the lymphoma cells tested. Compound 3a was the most active compound with 93 % cell grown inhibition and 71.04% of apoptosis.

El crecimiento celular así como la división celular son procesos altamente regulados, sin embargo, una notable excepción son las células cancerosas, las cuales han perdido sus mecanismos de control y regulación. En consecuencia el creciente interés por la búsqueda de sustancias antitumorales con alta eficiencia, baja toxicidad y la menor cantidad de reacciones adversas, nos condujo a sintetizar una familia de ocho diindolimetanos, los cuales fueron evaluados como inductores de apoptosis. Los resultados preliminares mostraron que el sustituyente y la posición en el grupo fenilo son importantes para esta actividad. El compuesto 3a de la serie estudiada mostró ser el más activo con un 93 % de la inhibición del crecimiento celular y una inducción de apoptosis de 71.04 %.

A free energy study for a phenyldiindolylmethanes serie was carried out. Applying the McLafferty equation to mass spectro metric data, we obtained two lineal correlations. The effect of the substituent over the fragment stability [M-H]+ was demostrated.

Se realizó el estudio de correlación de energías libres para una serie de 12 fenildiindolilmetanos. Aplicando la ecuación de McLafferty a los datos de espectrometría de masas, se obtuvieron dos correlaciones lineales en la que se muestra el efecto del sustituyente sobre la estabilidad del fragmento [M-H]+.